Endocrine Abstracts

Prepubertal gynaecomastia may be due to increased oestrogen resulting from excessive aromatase activity in extra glandular tissues. CYP19A1 gene on chromosome 15q21.2 encodes aromatase, the key enzyme for oestrogen biosynthesis. Tissue-specific promoters regulating the expression of aromatase activity have been demonstrated in placenta, ovary, testes, brain, skin fibroblasts and adipocytes. Mutations involving aromatase cytochrome P450 (P450arom) have been reported ...